Associate Scientist, Display Technologies

BigHat Biosciences is seeking a curious and motivated Associate Scientist to join the Display Technologies team. This individual will contribute to BigHat’s antibody discovery and engineering efforts and help generate high-quality data to improve BigHat’s machine learning models using display technologies, working closely with senior scientists and cross-functional teams.

Responsibilities

Support R&D projects advancing display technologies at BigHat that expands BigHat's antibody discovery capabilities and feed its ML models; Lead in the construction and QC of phage and yeast display libraries across diverse antibody formats (VHH, scFv, Fab) using standard molecular biology techniques (PCR, molecular cloning, electroporation); Execute phage and yeast display selections using naive and affinity and stability maturation libraries to discover and engineer antibodies with desired therapeutic properties; Express, purify, and characterize display-derived molecules using assays including ELISA, flow cytometry, BLI/SPR, CE-SDS, and others; Analyze selection results and contribute to discussions on next steps and future experimental design; Collaborate with BigHat’s Data Science and Machine Learning teams to inform library design and interpret selection data for model training; Present experimental plans and results during regular meetings with manager and science teams; Maintain thorough records using LIMS and electronic notebooks

Requirements

BS or MS in Biochemistry, Molecular Biology, Bioengineering, or a related field; 4+ years of hands-on laboratory experience (academic or industry); relevant internship or research experience welcome; Familiarity with general molecular biology techniques (PCR, molecular cloning, gel electrophoresis); Exposure to antibody biology, display technologies (phage or yeast), and protein expression; Demonstrated ability to follow protocols carefully, troubleshoot experiments, and maintain detailed lab records; Effective time management and clear written and verbal communication skills; Collaborative, team-oriented mindset with an eagerness to learn in a fast-paced startup environment

Nice to have

Experience with flow cytometry, ELISA, or other binding assays; Familiarity with NGS or automation platforms

Benefits

Bonus; Options; Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived); Dental and vision coverage through Guardian; Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more; 401(k) with company match; DTO, two weeks of company-wide shutdown, and 12 company holidays; Paid parental leave