Scientist II, Developability

BigHat Biosciences is looking for a hands-on, bench-driven scientist to drive antibody developability assessments that advance our Milliner Platform for AI-designed therapeutics. This is a primarily lab-based role where you'll spend the majority of your time at the bench executing and innovating on our developability workflows.

Responsibilities

Lead developability R&D projects: design, optimize, and execute high throughput developability assays to expand BigHat’s toolkit; Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization; Support late-stage characterization and IND-enabling studies, including formulation screening, stress testing, peptide mapping, and simulated administration studies, to rank and advance lead candidates; Serve as the Developability lead within project teams, guiding experimental strategy to address liabilities and hit program milestones; Work cross-functionally to automate and train colleagues on new and existing methods, build QC frameworks for monitoring assay performance, and adapt workflows to existing LIMS infrastructure; Proactively and independently analyze data, interpret scientific findings, propose next steps, and broadcast findings clearly across the organization

Requirements

PhD in Biochemistry or relevant discipline with 3+ year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered; Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS, including method development and optimization; Track record of translating complex data into clear results and recommended actions; Experience with protein structures and antibody engineering; Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost

Nice to have

Prior experience working in a dynamic start-up environment; Working as a project lead; Working with automation

Benefits

Bonus; Options; Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived); Dental and vision coverage through Guardian; Additional well-being benefits through Nayya, OneMedical, Wagmo, Rula, and more; 401(k) with company match; DTO, two weeks of company-wide shutdown, and 12 company holidays; Paid parental leave