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Senior Product Manager, Provider and RWD Health Systems Applications

Remote work

Publication date: 13/11/2026

Natera's RWD platform at the clinic connects an ecosystem of real-world evidence, molecular data, and clinical insights to deliver actionable information to physicians. We are seeking a Senior Product Manager to help build and scale physician-facing RWD applications. In this role, you'll own a physician-facing RWD application for a patient's molecular and clinical journey and workflow integrations behind it, partnering with cross-functional product teams, engineering, AI/ML teams, and clinical teams to deliver intuitive tools centered on enriched patient insights.

Responsibilities

Collaborate with clinical product management, EMR, user experience product management, marketing, medical and cross-functional teams to drive product strategy and roadmap; Drive integration of genomic tests into the platform as part of a unified oncology digitized experience; Work closely with AI/ML teams to build applications for patient-level and clinic-level insights, including cohort comparison, clinical trial matching, and cohort analytics; Partner with legal, privacy, and security so HIPAA obligations, PHI handling, and data-governance requirements are designed into the product; Own the single- and multi-patient views that bring a patient's molecular results and clinical events together in one physician-facing application; Integrate AI-powered clinical trial matching; Help reduce friction points at the provider and patient level to enroll in clinical trials; Partner across Natera to enable EMR/EHR integration and mobile access; Contribute to an analytics framework that captures user analytics; Support delivery of a physician-facing platform that highlights therapies, tracks treatment response, and monitors disease progression in real time; Ship tools and functionality to aid physician collaboration; Connect molecular and clinical findings to relevant treatment pathways and outcomes data; Partner with Product Marketing, MSL, Sales, and Clinical Operations on enablement, training, and adoption; Partner with the Health Systems BU to define, build, and launch a de-identified, aggregated research platform; Engage with physicians, KOLs, and academic collaborators to translate clinical needs into features; Help track KPIs centered on the physician experience with RWD at the clinic; Support representation of RWD at conferences, industry forums, and customer discussions as needed

Requirements

5+ years of product management or related experience, including experience in healthcare, engineering, genomics, or AI/ML; Deep understanding of the oncology domain with direct experience building requirements and collaborating with physicians; Experience building clinician-facing software that fits into real clinical workflows; Experience delivering AI/LLM-derived clinical data into provider-facing products, including human-in-the-loop review, confidence labeling, and data transparency; Backlog ownership: writing and grooming user stories in Jira and driving PM perspective in Agile ceremonies (sprint planning, standups, retros); Hands-on with data: comfortable writing SQL (or equivalent) to check status, investigate issues, and measure outcomes; Track record of setting product KPIs and moving them, with specifics on adoption, engagement, and quality; Fluency in oncology / genomics clinical concepts (staging, lines of therapy, biomarkers, MRD/ctDNA); Commitment to user-centered design thinking; Strong written and verbal communication skills with clinical, technical, and commercial audiences

Nice to have

Using AI tools day to day to prototype and draft specs; EHR integration experience (SMART on FHIR, HL7/FHIR, Epic or other EHR app ecosystems); Strong technical fluency, comfortable working with engineers, scientists, and data teams, and reasoning about what AI/ML and LLMs can and can't reliably do; Familiarity with PHI-handling applications, HIPAA, or regulated clinical software; Familiarity with FDA clinical decision support or SaMD considerations

Benefits

Comprehensive medical, dental, vision, life and disability plans for eligible employees and dependents; Free testing for employees and immediate families; Fertility care benefits; Pregnancy and baby bonding leave; 401k benefits; Commuter benefits; Employee referral program
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