Associate Director/Sr. Manager, Health Economics & Outcomes Research-Oncology

We are seeking a strategic, analytical, and highly collaborative leader to serve as our Associate Director/Senior Manager of Health Economics & Outcomes Research (HEOR) Oncology. In this high-impact role, you will lead the development and execution of health economic and outcomes evidence demonstrating the clinical and economic value of Natera’s precision molecular diagnostic technologies across oncology and emerging indications. You will develop health economic models, generate real-world and clinical-trial evidence, lead HEOR publication initiatives, and translate complex clinical and economic data into compelling evidence supporting market access, reimbursement, payer adoption, clinical adoption, and commercialization. Working across Medical Affairs, Clinical Development, Biostatistics, Market Access, Commercial, Marketing, Regulatory, and Business Development, you will help integrate HEOR evidence throughout the product lifecycle—from clinical development and evidence generation through publication, reimbursement, and payer adoption. This is a strategic role for an experienced HEOR professional who combines strong technical capabilities with scientific communication, business acumen, and the ability to influence cross-functional evidence strategy.

Responsibilities

Lead development, validation, and application of health economic models, including budget impact, cost-effectiveness, cost-utility, cost-consequence, ROI, decision-tree, Markov/state-transition, partitioned-survival, and other economic models; Partner with Clinical Development, Medical Affairs, Biostatistics, and cross-functional teams to integrate HEOR objectives into prospective clinical studies; Analyze clinical-trial, observational, and real-world datasets to evaluate healthcare resource utilization, cost of care, treatment pathways, diagnostic utilization, clinical utility, comparative effectiveness, patient outcomes, survival, budget impact, and quality-adjusted life years; Lead HEOR publication strategy and development of peer-reviewed manuscripts, scientific abstracts, conference posters, oral presentations, white papers, and technical reports; Partner with Market Access, Medical Affairs, Marketing, and Commercial teams to translate HEOR evidence into payer value propositions, budget impact summaries, value dossiers, reimbursement materials, health economic briefs, health-system value calculators, account-specific economic tools, and other evidence-based value communications; Develop and adapt health economic evidence and payer models for U.S. and international markets; Serve as strategic HEOR partner across Medical Affairs, Clinical Development, Biostatistics, Market Access, Commercial, Marketing, Regulatory, and Business Development; Collaborate with external consultants, academic investigators, KOLs, and research partners

Requirements

Advanced degree (PhD, PharmD, MD, DrPH, or Master's degree) in Health Economics, Outcomes Research, Epidemiology, Public Health, Biostatistics, Pharmacy, Health Services Research, or a related discipline; 5–10+ years of HEOR experience within biotechnology, pharmaceuticals, diagnostics, medical devices, consulting, academia, or a related healthcare environment; Demonstrated experience developing and applying health economic models and conducting outcomes research using clinical-trial and/or real-world datasets; Experience supporting payer evidence generation, reimbursement strategy, value dossiers, market access initiatives, and scientific publications; Deep understanding of health economic modeling, outcomes research, healthcare resource utilization, real-world evidence, cost-of-care analysis, comparative effectiveness, and value assessment methodologies; Demonstrated ability to develop and critically evaluate budget impact, cost-effectiveness, cost-utility, ROI, decision-tree, Markov/state-transition, and related economic models; Strong understanding of payer evidence requirements and ability to translate clinical and economic evidence into compelling value propositions; Ability to integrate HEOR endpoints and evidence requirements into clinical development and real-world research programs; Strong scientific writing and communication skills; Proven ability to work across functions and influence evidence strategy in a matrixed organization; Understanding of U.S. and international reimbursement environments and major HTA frameworks including ICER, NICE, CADTH, PBAC, IQWiG, and Japanese reimbursement processes

Nice to have

Experience with precision medicine, molecular diagnostics, companion diagnostics, ctDNA, molecular residual disease (MRD), donor-derived cell-free DNA (dd-cfDNA), next-generation sequencing, biomarker-guided treatment strategies, or oncology diagnostics is highly desirable; Familiarity with advanced economic and analytical tools such as Microsoft Excel, TreeAge Pro, R, SAS, STATA, Python, SQL, Tableau/Power BI, and statistical analysis software is preferred

Benefits

Annual performance incentive bonus; Long-term equity awards; Comprehensive health benefits (medical, dental, vision); 401(k) with company match; Generous paid time off and company holidays; Additional wellness and work-life benefits; Life and disability plans; Free testing for employees and immediate family; Fertility care benefits; Pregnancy and baby bonding leave; Commuter benefits; Employee referral program