Principal Research Scientist I, In Vivo CAR-T Biology

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

AbbVie is seeking an accomplished in vitro preclinical scientist to join the in vivo CAR Biology group as a Principal Research Scientist I. This individual will play a significant role in integrating emerging platform capabilities with novel CAR-T designs and discovery projects to advance next-generation in vivo CAR T-cell therapies from concept through IND-enabling studies.

Responsibilities

Function as a Principal Investigator within the in vivo CAR Biology in vitro preclinical team by defining original scientific hypotheses and research and development strategies for novel in vivo CAR T-cell therapies.; Anticipate and critically evaluate scientific advances or competitive threats and respond with appropriate new research proposals.; Collaborate with Quantitative Medicine, Biotherapeutics, Genetic Medicine, and Discovery Research mRNA-tLNP groups to design and functionally test novel CAR constructs that address key therapeutic challenges.; Lead laboratory project execution by translating therapeutic hypotheses into actionable plans, defining integrated timelines, milestones, dependencies, deliverables, and ownership, ensuring adherence and accountability, and partnering with workstream authors to flag schedule risks and implement mitigation plans.; Represent project teams by providing stakeholders with clear, timely updates on scientific strategy, experimental progress, key decisions, and project risks.; Mentor/supervise a team of one or more and evaluate the performance of those individuals, is accountable for the effective performance of the team/individuals.; Demonstrate creative 'out of the box' thinking to solve difficult problems and champion new technologies to achieve project goals.; Primary author of novel workflows, publications, presentations, regulatory documents and/or primary inventor of patents.; Present research findings and innovative ideas at leading scientific conferences to strengthen AbbVie’s scientific reputation and engagement with external stakeholders and collaborators.

Requirements

BS or equivalent education with typically 14+ years of experience, MS or equivalent education with typically 12+ years of experience, or PhD with typically 6+ years of experience in CAR-T discovery research, cell therapy, or immuno-oncology.; Expertise in designing, generating, and preclinically evaluating CAR-T candidates, experience developing next-generation in vivo lentiviral CAR-T platforms is strongly preferred.; Expertise in synthetic biology, T-cell biology, and immuno-oncology applied to CAR design and next-generation in vivo CAR-T platform innovation.; Experience developing complex, semi-automated experimental and analytical workflows and functional screening assays to improve the throughput, reproducibility, and efficiency of CAR-T candidate discovery, characterization, and selection.; Demonstrated capacity to function as a Principal Investigator by generating original technical ideas, defining research or development strategies, and leading multidisciplinary teams through execution and scientific decision-making.; Exceptional project management and prioritization skills, with demonstrated ability to define integrated research timelines, manage dependencies and competing priorities, establish clear ownership, hold contributors accountable, and proactively communicate and mitigate delivery risks.; Demonstrated success as a primary author of publications, presentations, or regulatory documents and/or as a primary inventor on patents, with a record of communicating complex scientific findings effectively to internal and external audiences.