Scientist III - LC/MS (Bioanalytical)

In this hands-on, laboratory-based Scientist role, you will design, develop, and execute bioanalytical methods and experiments supporting the advancement of new therapies, with a particular focus on large-molecule LC/MS applications. You will spend much of your time at the bench performing method development, optimization, and GxP-compliant validation; generating and analyzing data; evaluating assay performance; and conducting targeted and untargeted analyses using liquid chromatography and mass spectrometry. This is a full-time position with some flexibility in hours, occasional weekend, holiday, and evening work, and occasional travel.

Responsibilities

Lead assay development, validation, and sample analysis of biologics, proteins, peptides, ADCs, and/or biomarkers using LC/MS techniques in support of preclinical, clinical, and product release studies; Plan and direct experimental design for junior staff; Drive bioanalytical projects to align with client timelines; Frequent communication with clients to discuss technical details and provide project updates; Advise clients on LC/MS assay best practices; Author documents (methods, SOPs, reports); Statistical analysis of bioanalytical data; Review of documentation; Peer review raw data; Prepare reagents; Troubleshoot assays; Design assay runs independently; Responsible for prompt identification and notification of deviations; Write plans/reports for sample analysis; Order and keep accurate inventories of supplies and forecast future needs; Perform assays according to GLP guidance or SOPs; Other duties as needed; Supervise Analyst I/II/III (may supervise)

Requirements

Experience with development, validation and execution of chromatographic and mass spectrometric assays (LC/MS), and/or ability to perform most tasks associated with custom research planning and bench work; Must work effectively within team to meet objectives under time constraints; Ability to take direction well and multi-task; Detail oriented and highly organized; Demonstrated expertise in chromatographic assay development; Advanced capabilities in data analysis, data visualization and statistical analysis; LC/MS assay development and validation; Proficiency in Microsoft Word, Excel, Sciex OS/Analyst, MassLynx, Chromeleon, Watson LIMS, JMP, Graphpad Prism; Ability to develop chromatographic assays using HPLC or LC/MS/MS; Excellent oral and written communication skills; Bachelor's degree in chemistry, biochemistry, biotechnology, biology, immunology, or related field with not less than 12 years' experience in a scientific laboratory environment, or Master's degree in a related field with not less than 10 years' experience, or PhD in a related field with not less than 8 years' experience; Demonstrated expertise in developing chromatographic and mass spectrometric assays including LC/MS and LC/MS/MS for bioanalytical studies by extracting analytes from complex biological matrices (protein precipitation, liquid-liquid, solid phase, immunoprecipitation or other extraction techniques)

Nice to have

Experience working in a GxP environment; Ability to develop protein binding, CYP inhibition, CYP induction, or CYP phenotyping assays; Demonstrated expertise in chromatographic assay development

Benefits

Medical Insurance (HDHP with HSA; PPO); Dental Insurance; Vision Insurance; Flexible Spending Account (medical; dependent care); Short Term Disability; Long Term Disability; Life Insurance; Paid Time Off (4 weeks per year); Parental Leave; Paid Holidays (9 scheduled; 5 floating); 401k with Employer Match; Employee Referral Program