Staff Scientist, Research (Oncology Diagnostics)

Natera is seeking a Staff Scientist to join our Early Research Team. The primary focus of this role is to independently lead the research and development of novel next-generation sequencing (NGS) technologies. In this role, you will lead projects from ideation to prototype, specifically designing and optimizing high-complexity NGS methods to advance our oncology diagnostic portfolio. Success in this role requires a deep technical foundation in molecular biology and NGS plus a proven track record of industrial R&D leadership.

Responsibilities

Lead and manage the development of innovative NGS-based diagnostic assays from feasibility through optimization; Define project goals and plans with input from stakeholders and manage multiple project streams in parallel; Independently design and execute complex laboratory experiments; analyze and interpret results to guide research direction; Coordinate cross-functional efforts to meet milestones and collaborate closely with bioinformatics, statistics, and data science teams to ensure robust experimental design and data analysis; Mentor and guide junior scientists while promoting scientific rigor and best practices; Author high-quality protocols, technical reports, and study documentation; Communicate progress regularly to stakeholders, including departmental meetings and senior leadership; Contribute to risk management, strategy development, and continuous improvement of scientific workflows

Requirements

Ph.D. in molecular biology, genomics, or a closely related field; Minimum 8 years of relevant industry experience, or 2+ years postdoctoral research with 6+ years in industry; Proven experience in designing and advancing NGS-based diagnostics, preferably in the field of oncology; A strong technical foundation in molecular biology or chemistry; Deep mechanistic knowledge of NGS library preparation chemistry; Demonstrated ability to independently design and execute complex experiments (solid DOE skills); Creativity and ingenuity in solving high-ambiguity technical challenges; Experience leading research projects in an industrial setting

Nice to have

Experience with cfDNA or liquid biopsy assay development; Hands-on experience with NGS-based methylation detection and epigenomic workflows; Familiarity with translating early-stage research assays toward regulated product environments; Proficiency in statistical analysis tools such as Excel, JMP, R, or Python; Familiarity with bioinformatics workflows is a plus

Benefits

Annual performance incentive bonus; Long-term equity awards; Comprehensive medical, dental, vision, life and disability plans; 401(k) with company match; Generous paid time off and company holidays; Additional wellness and work-life benefits; Free testing for employees and immediate families; Fertility care benefits; Pregnancy and baby bonding leave; Commuter benefits; Employee referral program