Bioinformatics Manager (Oncology Product Development)

Natera is currently seeking a Bioinformatics Manager to join the Bioinformatics team focused on Oncology Product Development. In this role, the individual will manage a team of Bioinformaticians and Data Scientists and provide technical leadership in the design, development and validation of ctDNA-based diagnostic tests. This position requires extensive cross-functional collaboration with biostatistics, molecular biology, software engineering and commercial departments. The ideal candidate will have a strong background in bioinformatics and data science, optimally with experience in the analysis or modeling of DNA methylation data, and an established record of project and technical leadership.

Responsibilities

Lead the effort to develop, optimize, and improve tools and analysis pipelines for diagnostic tests, including the detection of cancer-associated variants or methylation patterns and the implementation of evidence-based quality control thresholds; Provide technical leadership for product development projects by representing the team in cross-functional interactions and moving products through the full development process, from research through commercial launch; Supervise bioinformatics scientists and data scientists, managing their technical contributions, prioritizing resources, and taking responsibility for their technical and professional development; Provide input on experiment design, analysis and interpretation based on expert understanding of Natera’s technology and relevant mathematical principles; Work at a high level of independence and responsibilities in carrying out assignments; Contribute to our intellectual property portfolio; Set standards for rigorous data analysis and lead the production of high-quality documentation

Requirements

Master’s degree or Ph.D. in a quantitative discipline (bioinformatics, engineering, applied mathematics, statistics, or similar); Minimum of 4-8 years of post-graduate experience in a data science and/or bioinformatics role and 1-3 years of experience as technical lead in diagnostics or a related field; Experience moving algorithm-based products through commercialization and launch in a medical or biological application such as diagnostic testing, medical imaging, or biotechnology; Experience using Python or R for scientific data analysis and visualization; Strong foundation in statistical modeling/machine learning, including probability theory and estimation/classification methods; Experience with analysis of next-generation sequencing data, preferably including algorithm development or optimization; Proven ability to apply mathematical principles to solve real estimation problems and implement practical solutions; Excellent analytical, problem-solving and decision-making skills to independently make sound judgments and find creative solutions to moderately complex problems; Experience leading technical projects, including defining and meeting project milestones, delegating tasks to more junior team members, and ensuring the quality of technical deliverables; Excellent communication skills and the desire to work in a dynamic and collaborative environment

Nice to have

Prior experience analyzing or modeling DNA methylation data

Benefits

Annual performance incentive bonus; Long-term equity awards; Comprehensive health benefits (medical, dental, vision); 401(k) with company match; Generous paid time off and company holidays; Additional wellness and work-life benefits; Comprehensive medical, dental, vision, life and disability plans; Free testing for employees and immediate families; Fertility care benefits; Pregnancy and baby bonding leave; 401k benefits; Commuter benefits; Employee referral program