Senior Scientist I, Antibody Engineering

The role: BigHat Biosciences is seeking an exceptional individual for a Senior Scientist I role on the antibody engineering & binder generation team to serve as a program team lead of therapeutic programs with external and internal partners, driving antibody discovery, design, optimization, and characterization.

Responsibilities

Lead cross-functional project teams (including Data Science, AI/ML, Engineering, Protein Sciences, Automation) on the execution of rapid, iterative multi-objective optimization to identify high-value therapeutic antibodies through gold-standard assays; Deeply understand target biology to better design antibodies that meet our candidate profile; Contribute expertise in antibody engineering approaches (including humanization, liability remediation, affinity tuning, format engineering, etc) to generate and optimize novel antibodies that meet design requirements; Collaborate closely with BigHat leadership and other cross-functional team members to ensure a tight linkage between strategy, research, and development components; Lead in-depth data analysis of each design cycle to better leverage experimental and computational approaches to reach our design goals; Effectively and regularly communicate results to key decision makers, the broader BigHat team, and to external partners

Requirements

Ph.D. in biochemistry, structural biology, protein engineering, or related fields; 5+ years of advanced research experience in an industry setting; Hands-on protein engineering expertise, including structure-guided design, affinity maturation, stability/developability optimization, and rational or computational approaches to antibody engineering; Experience working with diverse antibody formats such as complex multispecifics, T-cell engagers, antibody fragments, antibody-drug conjugates, etc.; Expertise in mammalian cell culture, immunoassay, molecular techniques, cell-based assays, protein expression and characterization (e.g., kinetics, SEC); Exceptional written, verbal, and visual communication skills; Experience presenting and communicating strategy and results to internal and external partners; Scientific track record and publication record; Strong data analysis and interpretation skills

Nice to have

Experience working with agentic software tools is a plus.

Benefits

Bonus; Options; Benefits