Senior Scientist I, Biomolecular Interactions

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

AbbVie's Biotherapeutics and Genetic Medicine, Protein Sciences Group, is seeking a highly skilled and self-motivated scientist to join our Biomolecular Interaction Team. This role offers the opportunity to make significant contributions to all Discovery Research Therapeutic Areas and Projects by providing analytical and functional characterization of our biopharmaceutical products, including monoclonal antibodies, multi-specifics and antibody-like biologics. The ideal candidate will have a strong understanding of high-throughput biologics screening and characterization methods (e.g., SPR, BLI, ELISA, FACS, etc.) and possess a solid foundation in protein sciences and antibody discovery with a proven ability to work effectively on cross-functional teams. This is an excellent opportunity for a highly motivated scientist to make a meaningful impact in a collaborative and innovative setting. Join us in bringing innovative medicines to patients!

Responsibilities

Independently develop and execute SPR (Biacore and Carterra platforms) assays to generate objective selection criteria for panels of antibodies, multispecifics, and antibody-like biologics.; Evaluate and integrate protein-protein interaction technologies (e.g., SPR, BLI, ELISA, etc.) to support therapeutic candidate selection, demonstrating strong problem-solving skills.; Implement high-throughput epitope binning for large panels of monoclonal antibodies and develop deep knowledge of antibody sequence/function relationships.; Perform antibody Fc characterization studies to support regulatory submissions.; Identify and solve technical problems independently, explore and develop new approaches to further advance innovative characterization and screening technologies.; Serve as a biologics lead for cross-functional teams and contribute scientific insights into multiple projects across various therapeutic areas, recognized and sought out as an expert in biomolecular interactions within the company and externally.; Provide project updates, analysis and advice to cross-functional teams and senior management.; Present original work internally across departments and at internal/external scientific conferences, may author or co-author peer-reviewed scientific papers or patents.

Requirements

PhD, MS or BS in Biochemistry, Biomedical Engineering or related field with typically 0-4 years (PhD), 8+ years (MS), or 10+ years (BS) of experience.; Experience in analytical/functional characterization of biologics using Surface Plasmon Resonance (SPR) platforms (e.g., Biacore and Carterra).; Experience of high throughput biologics screening with biochemical, biophysical, and cell-based methods.; Possessing broad technical knowledge of a variety of analytical, biophysical, and structural methods, such as SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS, etc. is a plus.; Extensive knowledge in related functional areas, such as protein structure and function, antibody engineering, protein production and analytics is a plus.; Excellent organizational skills and the ability to manage multiple projects simultaneously.; Team player with the ability to operate in a fast-paced multi-disciplinary environment.; Adapt to rapid changes in project priorities and timelines.; Candidate must be a goal-oriented team player with excellent verbal and written communication skills and strong can-do attitude.; Experience in managing internal/external collaboration is a plus.