Scientist - Cellular Immunology Preclinical

We are seeking a highly skilled and motivated Scientist with expertise in cell-based assays for CAR T cell therapy. As a key member of our research and development team, you will play a crucial role in advancing the field of cellular immunotherapy by developing in vitro, ex vivo, and in vivo assays to contribute to enhancing the safety and efficacy of CAR T cells in preclinical settings. This position offers an exciting opportunity to contribute to groundbreaking research that has the potential to revolutionize treatment for autoimmune disease patients.

Responsibilities

Conduct hands-on laboratory experiments following established protocols to maintain, expand, bank, and manage various cell lines, and generate CAR T cells; Perform and validate cytotoxicity and flow cytometry assays; Perform and validate ELISpot, ELISA, Luminex, MSD, and other assays as needed; Perform laboratory-associated tasks in accordance with Cabaletta Bio laboratory safety policies and SOPs; Oversee in vivo mouse studies and perform related ex vivo assays as needed; Ensure proper maintenance and cleanliness of laboratory equipment and workspaces; Maintain accurate, organized records and an electronic laboratory notebook; Analyze experimental data using basic statistical methods and software tools; Work collaboratively within a multidisciplinary team, actively participating in team meetings and discussions; Communicate experimental results and findings effectively to colleagues and supervisors through written reports and oral presentations.

Requirements

Ph.D. in Immunology, Cell Biology, Molecular Biology, or a related field with 0–2 years of experience, or a Master's degree with a minimum of 5 years of experience, or a Bachelor’s degree with a minimum of 10 years of relevant experience; Hands-on experience with cell culture and basic molecular biology techniques; General laboratory skills, including aseptic techniques and human tissue handling; Prior experience and proficiency with mammalian cell culture using aseptic techniques; Experience with primary cell husbandry, cytotoxicity assays, and flow cytometry; Highly organized with the ability to work independently; High level of flexibility to support a variety of activities and the ability to learn new techniques outside of existing areas of expertise; Strong team orientation and passion for continuous self-development; Excellent organizational skills, attention to detail, and the ability to follow protocols accurately; Effective written and verbal communication skills to share experimental findings and collaborate with team members; Experience working in a research or industry setting related to immunology and/or cell therapy; Experience in the biotechnology industry or a startup environment; Enthusiasm for learning and contributing to innovative research in the field of CAR T cell therapy.

Nice to have

Prior involvement in animal studies or hands-on animal handling is advantageous; Extensive hands-on experience with primary immune cell cultures and related assays is advantageous

Benefits

Health and retirement; PTO; stock option plans