Senior Research Associate & Group Leader - DMPK

Senior Research Associate - DMPK

- Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and plasma protein binding assays

- Develop, optimise, and execute analytical methods using LC-MS/MS and complementary detection modalities (absorbance/fluorescence-based assays)

- Support development and validation of new ADME assays to expand the group’s scientific capabilities

- Process and analyse experimental data using GraphPad Prism, MS Excel, and mass spectrometry software platforms (e.g., Sciex)

- Prepare clear experimental documentation, study summaries, and reports for internal teams and external collaborators

- Coordinate with third-party collaborators for pharmacokinetic (PK) studies, including in vivo animal studies where applicable

- Present experimental results and scientific observations in internal meetings, project reviews, and cross-functional discussions

- Work closely with colleagues across biology, and ADME groups to provide integrated drug discovery support alongside chemistry teams

- Support laboratory operations including reagent ordering, inventory management, assay consumables tracking, and coordination of laboratory logistics

Group Leader - DMPK

- Lead, mentor, and develop a team of scientists engaged in In-Vitro ADME/DMPK studies.

- Oversee the design, execution, analysis, and interpretation of In-Vitro ADME studies, including metabolism, transporter, and drug-drug interaction assessments.

- Manage external CRO partnerships for In-Vivo PK studies, ensuring timely execution, data quality, and delivery.

- Provide scientific guidance and DMPK strategies to support drug discovery and development projects.

- Analyze and interpret study data, prepare technical reports, and present findings to internal and external stakeholders.

- Serve as the primary scientific point of contact for clients, ensuring effective communication and project delivery.

- Support proposal preparation, project scoping, contract review, and project onboarding activities.

- Manage study budgets, resource allocation, and operational efficiency.

- Drive continuous improvement initiatives and implement best practices across DMPK operations.

- Collaborate closely with cross-functional teams to integrate ADME/DMPK data into project decisions.

- Prepare and present monthly MIS reports, including project status, resource utilization, risks, and key performance metrics.

Requirements

Senior Research Associate - DMPK; Master's in Lifescience with 4-5 years of working experience with LC-MS/MS, HPLC, bio-analytical studies etc.; Strong understanding of laboratory techniques, analytical instrumentation, and underlying scientific principles; Practical experience working in biotechnology laboratories including cell culture facilities and in vitro ADME assay environments; Good theoretical and practical knowledge of cell culture systems (established cell lines) and ADME assays such as microsomal stability, permeability, CYP inhibition, plasma stability, and plasma protein binding; Ability to troubleshoot experimental challenges and apply sound scientific judgment; Self-driven and capable of managing multiple tasks while working within demanding project timelines; Strong attention to detail and commitment to maintaining high scientific and data quality standards; Excellent interpersonal skills with the ability to collaborate effectively across multidisciplinary teams; Strong communication skills for interacting with internal teams, collaborators, and stakeholders; Highly organised with the ability to function effectively in a fast-paced research environment; Curiosity, enthusiasm for science, and a desire to contribute to innovative drug discovery programs; A positive and collaborative mindset with the ability to contribute to a supportive and high-performance team culture at o2h; Group Leader - ADME/DMPK; Ph.D. in Pharmaceutical Sciences, Pharmacology, or a related Life Sciences discipline.; 10–15 years of relevant experience in DMPK, In-Vitro ADME, and Pharmacokinetic sciences within pharmaceutical, biotechnology, or CRO organizations.; Proven experience in leading scientific teams and managing complex research projects.; Strong expertise in In-Vitro ADME studies and interpretation of DMPK data.; Experience managing CRO collaborations and outsourced In-Vivo PK studies.; Excellent leadership, project management, communication, and stakeholder management skills.; Strong analytical and problem-solving capabilities with a client-focused approach.; Ability to communicate complex scientific concepts effectively to diverse audiences.