Supervisor, Oncology RUO

Join Natera’s Oncology Research Use Only (RUO) team as a Supervisor for the Signatera Plasma Team. You will direct laboratory staff executing cell-free DNA (cfDNA) extraction, library preparation, and Next-Generation Sequencing (NGS) workflows to advance our personalized Minimal Residual Disease (MRD) assays. Every sample represents a real person, and you will ensure that all lab processes operate with the pace and precision required to support our clinical pipeline.

Responsibilities

Oversee the daily scheduling of employees executing DNA extractions, library preparation, Nucleic Acid Quality Control (QC), and NGS workflows; Conduct regular 1:1 meetings to deliver unvarnished, data-backed performance evaluations and guide career development; Take ownership of daily lab operations by directly executing sample processing alongside the team to maintain throughput; Serve as the primary technical point of contact, using data to guide team members on data interpretation, next steps, and troubleshooting; Execute process development and method/instrument testing to increase operational precision and scale; Use data to identify lab process deviations, root-cause the underlying issues, and document findings via nonconformance reports to drive corrective action; Draft, generate, and rigorously review Standard Operating Procedures (SOPs) and work instructions; Maintain precise records of lab work using Google Sheets, Microsoft Excel, and internal Laboratory Information Management Systems (LIMS); Ensure accurate, ethical, and appropriate management of samples in strict compliance with all applicable federal regulations; Think team by partnering directly with Oncology RUO peer groups to eliminate bottlenecks and optimize sample processing without needing translation layers; Present data-backed summaries on team activities, project milestones, and timeline adherence; Adapt to evolving science and operational needs, taking ownership of tasks that move the work forward without waiting for a finished playbook; Handle protected health information (PHI) in paper and electronic formats as required to perform duties; Complete required HIPAA/PHI privacy and security training within the first 30 days of hire and maintain current status on all training

Requirements

BS/BA in a biological science or equivalent; 3 to 4 years of related laboratory experience; Must pass a post-offer criminal background check; Direct hands-on experience with nucleic acid techniques, including isolation, purification, quantification, amplification, and hybridization capture; Extensive familiarity with rigorous pipetting practices using single- and multi-channel micropipettes and serological pipettes; Hands-on experience operating Laboratory Automation platforms (e.g., Hamilton, Tecan, Biomek, QIAsymphony); Hands-on experience with library preparation and NGS platforms; Proficiency with LIMS and database software; Proficiency with Microsoft Office and Google Workspace applications; Ability to think analytically, testing assumptions with data to troubleshoot and solve complex problems; Clear, direct oral and written communication skills to present data and identify operational improvements; Demonstrated interpersonal skills to build effective working relationships within the functional area; Ability to manage competing priorities while operating with pace and precision in an evolving scientific environment

Nice to have

Prior team management experience is highly preferred; Experience leading a lab team, spanning scheduling, training, workload prioritization, and building an execution-focused culture, is a plus

Benefits

Comprehensive health benefits (medical, dental, vision); 401(k) with company match; Generous paid time off and company holidays; Additional wellness and work-life benefits; Life and disability plans; Free testing for employees and immediate family; Fertility care benefits; Pregnancy and baby bonding leave; Commuter benefits; Employee referral program