Associate Director / Director of Product Management, Signatera Hematologic Oncology (Heme)

The Associate Director / Director of Product Management, Signatera Heme will own the product strategy and roadmap for Signatera in hematologic malignancies, starting with multiple myeloma and lymphomas. This person will work in a highly matrixed environment with the Foresight BU, R&D, Lab Operations, Software Engineering, Medical Affairs, Marketing, Business Development, and Regulatory. The role combines product management, market entry as a laboratory developed test (LDT), evidence generation, analytics, and clinical trial product support, including trials run under IUO and IVD pathways.

Responsibilities

Develop and execute the Signatera product roadmap for hematologic malignancies, beginning with multiple myeloma and lymphomas; Lead market entry planning for Signatera in heme as an LDT, including clinical validation, CLIA and state requirements, market access/reimbursement, and launch readiness; Define product requirements for blood-based malignancies with R&D, Lab Operations, and Software Engineering; Lead product support for clinical trials using Signatera in heme, including IUO and path toward IVD; Partner with Regulatory, Clinical, and Business Development on trial start-up and companion diagnostic opportunities; Build product performance metrics and dashboards; Partner with Medical Affairs and Clinical on evidence generation strategy; Guide product development for Signatera Genome in heme; Conduct Voice of Customer interviews, market research, and competitive intelligence; Engage with key opinion leaders, advisory boards, and congresses; Work with Marketing on product positioning, launch plans, pricing, and collateral; Build business cases and financial models; Present strategy and data-driven recommendations to executive leadership; Perform other duties as assigned

Requirements

Bachelor's degree in life sciences, statistics, engineering, or a related field; 5+ years of experience in product management, product marketing, or market analytics at a diagnostics, biotech, or pharmaceutical company; Working knowledge of oncology molecular testing, next-generation sequencing (NGS), and biomarkers, including NGS bioinformatic workflows and genomic data analysis; Experience with clinical trials and experience in IUO and IVD regulated environments; Experience bringing a molecular test to market as an LDT, including clinical validation and laboratory requirements; Experience designing or supporting clinical evidence generation; Understanding of MRD in multiple myeloma and lymphomas; Understanding of how somatic variants are detected in whole genome sequencing; Understanding of LDT market entry requirements and evidence needed for clinical adoption and payer coverage; Ability to translate customer and clinical needs into clear product requirements; Strong analytical skills; Basic financial modeling skills; Proficiency with MS Excel, Word, and PowerPoint; Ability to lead without authority and influence cross-functional teams; Strong written and oral communication skills; Availability during Pacific time hours; 30-40% travel

Nice to have

Hematologic oncology experience, especially multiple myeloma and lymphoma; MRD experience; Experience with data analysis using SQL, Snowflake, or similar tools; Familiarity with a high complexity molecular laboratory, including cfDNA or plasma workflows; In-depth knowledge of whole genome sequencing and variant types, including structural, single nucleotide, and phased variants; Prior KOL engagement and external customer-facing experience; Advanced degree (MS, PhD, or MBA)

Benefits

Comprehensive medical, dental, vision, life and disability plans for eligible employees and dependents; Free testing for employees and immediate families; Fertility care benefits; Pregnancy and baby bonding leave; 401k benefits; Commuter benefits; Employee referral program